7ALPHA-甲氧基迷迭香酚 TN1334

Product Introduction
Bioactivity


英文名: 7-Methoxyrosmanol

描述: 7-Methoxyrosmanol (7-O-Methylrosmanol) 是一种酚类二萜，从迷迭香中分离得到，可抑制 PEPCK 和 G6Pase 启动子的 cAMP 反应。

体外活性: In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid and carnosol) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol and semisynthetic derivatives (7-O-Methylrosmanol, 7-O-ethylrosmanol, and 11,12-O,O-dimethylcarnosol) were prepared. The inhibitory activity of all six compounds against HIV-1 protease was tested. The carnosic acid showed the strongest inhibitory effect (IC90 = 0.08 micrograms/ml). The same compound was also assayed against HIV-1 virus replication (IC90 = 0.32 micrograms/ml).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 12 mg/mL (33.29 mM)


关键字: inhibit | 7-Methoxyrosmanol | Inhibitor | 7Methoxyrosmanol | 7 Methoxyrosmanol

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相关库: Terpene Natural Product Library | Polyphenolic Natural Product Library | Selected Plant-Sourced Compound Library | Membrane Protein-targeted Compound Library | Human Metabolite Library | GPCR Compound Library | Human Endogenous Metabolite Compound Library Plus | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Natural Product Library

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