山金车内酯 D TN1405

Product Introduction
Bioactivity


英文名: Arnicolide D

描述: Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。

体外活性: In this study, we found that two sesquiterpene lactones, isobutyroylplenolin and Arnicolide D, from Centipeda minima L. (Compositae) exerted stronger cytotoxic activity than cisplatin on the human colon carcinoma HT-29 cell line. Furthermore, the cytotoxicity of these two compounds on normal cells was weaker than that of cisplatin.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2.75 mg/mL (8.27 mM)


关键字: Mammalian target of Rapamycin | Phosphoinositide 3-kinase | inhibit | Inhibitor | Caspase | mTOR | PKB | Akt | PI3K | Arnicolide D | STAT | Protein kinase B

相关产品: Urolithin B | Chromeceptin | PHT-427 | CCT128930 hydrochloride | A-674563 HCl (552325-73-2(free base)) | Bakkenolide A | TD52 | MBM-55S | Communic acid | Zeylenone

相关库: Anti-Tumor Natural Product Library | Terpene Natural Product Library | Transcription Factor-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Natural Product Library for HTS | Anti-Pancreatic Cancer Compound Library | Metabolism Compound Library | RO5 Drug-like Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途