假马齿苋皂苷 VII TN1424
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 94443-88-6 | ¥1,620.00 | 询底价 |
25 mg | 94443-88-6 | ¥19,900.00 | 询底价 |
5 mg | 94443-88-6 | ¥5,210.00 | 询底价 |
10 mg | 94443-88-6 | ¥9,570.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Bacopaside X
描述: Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
体外活性: The compounds were docked into 5-HT1A, 5-HT2A, D1, D2, M1 receptors and acetylcholinesterase (AChE) using AutoDock and their central nervous system (CNS) drug-like properties were determined using Discovery Studio molecular properties and ADMET descriptors. The compounds were screened in vitro using radioligand receptor binding and AChE inhibition assays. In silico studies showed that the parent bacosides were not able to dock into the chosen CNS targets and had poor molecular properties as a CNS drug. In contrast, the aglycones and their derivatives showed better binding affinity and good CNS drug-like properties, were well absorbed through the intestines and had good blood brain barrier (BBB) penetration. Among the compounds tested in vitro, ebelin lactone showed binding affinity towards M1 (Ki = 0.45 μM) and 5-HT2A (4.21 μM) receptors. Bacoside A and Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Bacopaside X
相关产品: Pardoprunox hydrochloride | Nomifensine | Raclopride | Lurasidone hydrochloride | UCSF924 | Remoxipride hydrochloride | Trifluoperazine dihydrochloride | Oxidopamine hydrochloride | Quetiapine hemifumarate | Fipexide
假马齿苋皂苷 VII TN1424信息由TargetMol中国为您提供,如您想了解更多关于假马齿苋皂苷 VII TN1424报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途