BETA-羟基异戊酰紫草素 TN1440

Product Introduction
Bioactivity


英文名: Beta-Hydroxyisovalerylshikonin

描述: Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物，具有抑制PTK 的作用， 对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用，可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。

体外活性: By using different chromatographic techniques and appropriate spectroscopic methods, the seven naphthoquinones were described: deoxyshikonin ( 1 ), isobutyrylshikonin ( 2 ), α±-methylbutyrylshikonin ( 3 ), acetylshikonin ( 4 ), Beta-Hydroxyisovalerylshikonin( 5 ), 5,8-O-dimethyl isobutyrylshikonin ( 6 ) and 5,8-O-dimethyl deoxyshikonin ( 7 ). Among the tested compounds, 3 and 4 exhibited the highest antibacterial activities toward all tested bacterial species (MIC50 and MIC90 for gram positive bacteria: 6.40 μg/mL-12.79 μg/mL and 6.82 μg/mL-13.60 μg/mL, respectively; for gram negative bacteria: 4.27 μg/mL-8.53 μg/mL and 4.77 μg/mL-9.54 μg/mL, respectively). Also, naphthoquinones 3 and 4 exhibited strong cytotoxic activity against MDA-MB-231 cells (IC50 values 86.0 μg/mL and 80.2 μg/mL, respectively), while compounds 1 , 3 , 4 and 5 significantly decreased viability of HCT116 cells (IC50 values of 97.8 μg/mL, 15.2 μg/mL, 24.6 μg/mL and 30.9 μg/mL, respectively)[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mg/mL (25.75 mM)


关键字: inhibit | Inhibitor | ErbB-1 | BetaHydroxyisovalerylshikonin | EGFR | Src | Beta Hydroxyisovalerylshikonin | Epidermal growth factor receptor | b-Hydroxyisovalerylshikonin | HER1 | Beta-Hydroxyisovalerylshikonin | β-Hydroxyisovalerylshikonin

相关产品: WS3 | Alflutinib | AV-412 | Benidipine hydrochloride | EGFR-IN-87 | Mavelertinib | Tyrphostin B44, (+) enantiomer | Nimotuzumab | JND3229 | CL-387785

相关库: Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Pyroptosis Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | RO5 Drug-like Natural Product Library | Glycolysis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途