漆黄素 ( 紫铆素) TN1461

Product Introduction
Bioactivity


英文名: (-)-Butin

描述: (-)-Butin (Butin) 是 Butin 的 S 对映体。其中 Butin 是一种分离自黄檀的心材中的生物活性黄酮类化合物，具有显著的抗血小板、抗氧化、抗炎作用。

体外活性: The antioxidant function of manganese superoxide dismutase (Mn SOD) is important in preventing oxidative stress. While exposure to H2O2 reduced the expression of Mn SOD in Chinese hamster lung fibroblast (V79-4), the addition of Butin restored Mn SOD expression at both the mRNA and protein levels, resulting in increased Mn SOD activity. The transcription factor NF-E2-related factor 2 (Nrf2) regulates Mn SOD gene expression by binding to the antioxidant responsive element (ARE). Butin enhanced the nuclear translocation and ARE-binding activity of Nrf2, which was decreased by H2O2. The siRNA-mediated knockdown of Nrf2 attenuated Butin-induced Mn SOD expression and activity. Further, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, Akt) contributed to the ARE-driven Mn SOD expression. Butin activated PI3K/Akt and exposure to either LY294002 (a PI3K inhibitor), Akt inhibitor IV (an Akt-specific inhibitor), or Akt siRNA suppressed the Butin-induced activation of Nrf2, resulting in decreased Mn SOD expression and activity. Finally, the cytoprotective effect of Butin against H2O2-induced cell damage was suppressed by the siRNA-mediated knockdown of Mn SOD[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (183.65 mM)


关键字: inhibit | Inhibitor | ()Butin | ( ) Butin

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相关库: Anti-Tumor Natural Product Library | PI3K-AKT-mTOR Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Angiogenesis related Compound Library | Chinese Pharmacopoeia Natural Product Library | Anti-Lung Cancer Compound Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library

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