美洲茶酸 TN1477

Product Introduction
Bioactivity


英文名: Ceanothic acid

描述: Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.

体外活性: Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from Ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-Ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Ceanothic acid

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