襄五脂素 TN1485
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 78919-28-5 | ¥3,330.00 | 询底价 |
1 mL | 78919-28-5 | ¥2,320.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Chicanine
描述: Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
体外活性: In this study, Chicanine, one of the major lignan compounds of S. chinesis, was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (RAW 264.7 cells). Chicanine was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO) and Prostaglandin E (2) (PGE2) production and nuclear factor-κB (NF-κB) signaling in LPS-stimulated RAW 264.7 cells with no cytotoxic effects. Treatment of RAW 264.7 cells with Chicanine down-regulated LPS-induced expression of pro-inflammatory cytokines including TNFα±, IL-1β, MCP-1, G-CSF, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and also IκB-α± phosphorylation[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Chicanine
相关产品: Sophocarpine | Veraguensin | Berbamine dihydrochloride | Morusin | Flavoglaucin | Rubioncolin C | TAK-243 | Lidocaine | BI-69A11 | methyl chlorogenate
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途