大花红天素 TN1532
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 63026-02-8 | ¥1,050.00 | 询底价 |
5 mg | 63026-02-8 | ¥950.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Crenulatin
描述: Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L group, respectively; the mechanism is related to the alterations of Fas/Bcl-2 expression and caspase-3 activity.
体外活性: The following terminal concentrations of Crenulatin were used in the study: 25 mg/L and 100 mg/L. Apoptosis of mouse cerebral microvascular endothelial cells (bEnd. 3 cell line) was evaluated by flow cytometer, immunocytochemical assay (Fas, Bcl - 2) and Western blotting (caspase - 3) after culture for 24 h. Compared with control group, apoptosis of bEnd. 3 cells in 25 mg/L group was significantly inhibited ( P 0.05), but apoptosis in the 100 mg/L group was significantly increased (P 0.05). In apoptosis inhibited group, the Fas immunocytochemical staining was weaker, the positive cells were significantly decreased ( P 0.05) and caspase - 3 expression was decreased compared with control group; however, the Bcl - 2 staining was stronger and the positive cells were significantly increased ( P 0.05). On the other hand, in apoptosis increased group ( 100 mg/L group), the changes were just opposite.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Crenulatin
相关产品: Jaceosidin | S63845 | Triacetylresveratrol | Panaxynol | Allethrin | A-385358 | BI-3802 | AZD4320 | BT2 | Cedrin
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途