表木兰脂素A TN1610

Product Introduction
Bioactivity


英文名: Epimagnolin A

描述: Epimagnolin A 是一种糠醛木脂素，具有中等的抗疟原虫活性，IC50值为5.7 μg/mL。

体外活性: A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study.?it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.?Furthermore, it was investigated the modulating effects of epimagnolin A on mitogen-activated protein kinase, nuclear factor-kappa B (NF-κB), and activator protein 1 (AP-1) activities.?Phosphorylation of p38 and nuclear translocation of p50 and c-Jun were down-regulated by epimagnolin A in the PMA-stimulated THP-1 cell.?The results revealed that epimagnolin A attenuated the binding affinity of NF-κB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells.?These results suggest that epimagnolin A can be a useful drug for the treatment of inflammatory diseases[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 12 mg/mL (28.81 mM)


关键字: furfuran | inhibit | Inhibitor | Parasite | Epimagnolin A | lignan | antiplasmodial

相关产品: Nifurtimox | Triclabendazole | MMV390048 | Fexinidazole | Febantel | Antiparasitic agent-20 | Febrifugine | Nimorazole | Hydroxychloroquine sulfate | Atovaquone

相关库: Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Anti-Parasitic Compound Library | Natural Product Library for HTS | Antiparasitic Natural Product Library | RO5 Drug-like Natural Product Library | Bioactive Compound Library | Natural Product Library | Anti-Infection Compound Library

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