黄诺马苷 TN1644

Product Introduction
Bioactivity


英文名: Flavanomarein

描述: Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。

体外活性: The present study aimed to identify the active compounds of Coreopsis tinctoria and to investigate the molecular mechanisms underlying its effects on lipid dysregulation by measuring lipid levels, reactive oxygen species, lipid peroxidation and fatty acid synthesis. The present results demonstrated that snow chrysanthemum aqueous extracts significantly reduced serum lipid levels and oxidative stress in vivo. The main compounds that were isolated were identified as Flavanomarein (compound 1) and eriodictyol 7-O-β-D glucopyranoside (compound 2). Compounds 1 and 2 demonstrated potent antioxidative properties, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs). Compound 2 was revealed to suppress the elevation of triglyceride levels and inhibit lipid peroxidation following FFA treatment. In addition, it was demonstrated to significantly reduce intracellular levels of reactive oxygen species and improve the mitochondrial membrane potential and adenosine triphosphate levels, thus protecting mitochondrial function in FFA-treated HepG2 cells. Furthermore, compound 2 markedly suppressed the protein expression levels of disulfide-isomerase A3 precursor and fatty acid synthase, thus suppressing FFA-induced lipogenesis in HepG2 cells[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (133.22 mM)


关键字: antioxidative | PI3K | antihypertensive | Smad | anti-hyperlipidemic | 6-hydroxydopamine | NF-κB | TGF-β1 | diabetic | nephropathy | inhibit | Flavanomarein | Inhibitor | AKT | Syk | antidiabetic

相关库: Antioxidant Compound Library | Anti-Tumor Natural Product Library | Oxidation-Reduction Compound Library | Polyphenolic Natural Product Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Flavonoid Natural Product Library | Covalent Inhibitor Library | Natural Product Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途