灵芝酸 C2 TN1661

Product Introduction
Bioactivity


英文名: Ganoderic acid C2

描述: Ganoderic acid C2 是分离自灵芝的一种三萜化合物， 具有潜在的抗肿瘤生物活性，以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose reductase 具有很高的抑制活性，IC50为 3.8 µM。

体外活性: The metabolites and pharmacokinetics of Ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis.

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (96.40 mM)


关键字: Ganoderic acid C-2 | Inhibitor | Ganoderic acid C 2 | Ganoderic acid C2 | inhibit

相关产品: Poliumoside | Ponalrestat | Isoliquiritigenin | Sorbinil | DL-Glyceraldehyde | Risarestat | Gonadorelin Acetate (33515-09-2 free base) | D-Methionine sulfoxide | Sulindac sulfone | Finasteride

相关库: Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Endocrinology-Hormone Compound Library

灵芝酸 C2 TN1661信息由TargetMol中国为您提供，如您想了解更多关于灵芝酸 C2 TN1661报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途