灵芝酸 DM TN1663

Product Introduction
Bioactivity


英文名: Ganoderic acid DM

描述: Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.

体外活性: GADM effectively inhibited cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells. GADM both concentration- and time-dependently mediated G1 cell cycle arrest and significantly decreased the protein level of CDK2, CDK6, cycle D1, p-Rb and c-Myc in MCF-7 cells. Moreover, GADM obviously induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells. Besides, we also showed that GADM elicited DNA damage as measured by comet assay which is a sensitive method for DNA damage detection. γ-H2AX, a marker of DNA damage, was also slightly up-regulated after treated with GADM for 6h, suggesting that the G1 cell cycle arrest and apoptosis induced by GADM may be partially resulted from GADM-induced DNA damage[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Ganoderic acid DM

相关产品: 3-Methoxybenzamide | PARP-1-IN-4 | Lasiodin | Senaparib | Verbascoside | PARP10-IN-3 | 1,5-Isoquinolinediol | Veliparib | Niraparib (R-enantiomer) | Pamiparib

灵芝酸 DM TN1663信息由TargetMol中国为您提供，如您想了解更多关于灵芝酸 DM TN1663报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途