盐酸骆驼蓬酚 TN1724

Product Introduction
Bioactivity


英文名: Harmalol hydrochloride

描述: Harmalol hydrochloride (Harmidol hydrochloride) 是一种可从Peganum harmala L.的种子中提取出来的β-咔啉生物碱。Harmalol hydrochloride 是Harmaline 的主要代谢产物，在转录和翻译后水平上显著抑制二恶英介导的 CYP1A1 诱导。Harmalol hydrochloride 在去氧肾上腺素或KCl 预先收缩的分离大鼠胸主动脉制剂中显示出血管松弛活性。 Harmalol hydrochloride 具有抗氧化活性.

体外活性: Harmalol (0.5-12.5 μM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.[1]Harmalol (25 μM) reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells.[2]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (380.2 mM)


关键字: Harmidol Hydrochloride | Harmalol Hydrochloride

相关产品: Salvianolic Acid C | Metyrapone | Hypaconitine | Cobicistat | Schisandrol B | Ticagrelor | 6',7'-Dihydroxybergamottin | CYP4A11/CYP4F2-IN-1 | Ambroxol | Doxepin hydrochloride

相关库: Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Alkaloid Natural Product Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Bioactive Compound Library

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