4,2',4'-三羟基-6'-甲氧基查耳酮 TN1727

Product Introduction
Bioactivity


英文名: Helichrysetin

描述: Helichrysetin 是从豆蔻果实中分离出的一种天然产物，是一种 DNA 结合抑制剂，可抑制原位导管癌DCIS 的形成。它抑制细胞生长，可诱导 A549 细胞凋亡。

体外活性: Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C (1) and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes. The known compounds were identified to be panduratin A (2), hydroxypanduratin A (3), Helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6). The structures of all compounds were elucidated on the basis of chemical and spectroscopic methods. It was found that 3 possessed the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 (IC50 = 18.7 microM), whereas other compounds exhibited only mild activity.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (78.59 mM)


关键字: Inhibitor | Apoptosis | growth | Helichrysetin | DCIS | inhibit | cell | cycle | ID2 | anticancer

相关产品: 3-Nitropropanoic acid | L-Theanine | Dihydrorotenone | Nirogacestat | Eriocitrin | (S)-(+)-Rolipram | Infigratinib | Rottlerin | Nimbolide | HBDDE

相关库: Anti-Tumor Natural Product Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Anti-Cancer Active Compound Library | Flavonoid Natural Product Library | RO5 Drug-like Natural Product Library | Anti-Viral Compound Library | Bioactive Compound Library

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