化合物Hypophyllanthin TN1757

Product Introduction
Bioactivity


英文名: Hypophyllanthin

描述: Hypophyllanthin 是珠子草中的一种木脂素，能直接抑制 P-gp 的活性，具有很强的抗炎活性。

体外活性: The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. Hypophyllanthin and phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (232.29 mM)


关键字: Inhibitor | CD243 | Pgp | inhibit | Hypophyllanthin | ABCB1 | P-glycoprotein | P-gp | Cluster of differentiation 243 | Multidrug resistance protein 1 | MDR1

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相关库: Anti-Tumor Natural Product Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Natural Product Library for HTS | Metabolism Compound Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途