异水飞蓟宾A TN1804
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 142796-21-2 | ¥6,590.00 | 询底价 |
1 mg | 142796-21-2 | ¥1,660.00 | 询底价 |
5 mg | 142796-21-2 | ¥2,890.00 | 询底价 |
10 mg | 142796-21-2 | ¥4,220.00 | 询底价 |
50 mg | 142796-21-2 | ¥8,890.00 | 询底价 |
1 mL | 142796-21-2 | ¥2,960.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Isosilybin A
描述: Isosilybin A 是从水飞蓟中分离出来的一种黄酮木脂素,可抑制癌细胞增殖并诱导 G1 期停滞和凋亡,通过靶向 Akt-NF-κB-雄激素受体轴激活前列腺癌细胞的凋亡机制,具有抗前列腺癌活性。
体外活性: To investigate the effects of milk thistle extract and its main flavonolignans (silybin A, silybin B, Isosilybin A and isosilybin B) on CYP2C8 activity at relevant concentrations, the effect of milk thistle extract and the flavonolignans on CYP2C8 enzyme activity was studied in vitro using human liver microsomes (HLM) incorporating an enzyme-selective substrate for CYP2C8, amodiaquine. Metabolite formation was analyzed using liquid chromatography-tandem mass spectrometry (LC/MS-MS). The concentration causing 50% inhibition of enzyme activity (IC50) was used to express the degree of inhibition. Isosilibinin, a mixture of the diastereoisomers Isosilybin A and isosilybin B, was found to be the most potent inhibitor, followed by isosilybin B with IC50 values (mean ± SE) of 1.64 ± 0.66 μg/mL and 2.67 ± 1.18 μg/mL, respectively. The rank order of observed inhibitory potency after isosilibinin was silibinin > Isosilybin A > silybin A > milk thistle extract > and silybin B[1]
存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 90 mg/mL(186.55 mM)
关键字: Apoptosis | inhibit | Inhibitor | Isosilybin A
相关产品: Taurochenodeoxycholic Acid | (±)-α-Bisabolol | Tubastatin A | Tacedinaline | CITCO | AG1024 | 3-Methoxy-9H-Carbazole | Millepachine | Parthenolide | Adapalene
相关库: Membrane Protein-targeted Compound Library | Flavonoid Natural Product Library | Rare Natural Product Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途