桑皮酮H TN1849

Product Introduction
Bioactivity


英文名: Kuwanon H

描述: Kuwanon H 是分离自桑白皮的黄酮类化合物，具有拮抗非肽类蛙皮素受体的活性。Kuwanon H 特异性抑制细胞内胃泌激素释放肽 CRP 与GRP-preferring 受体的结合，Ki 为 290 nM。

体外活性: Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (65.72 mM)


关键字: Kuwanon H | Inhibitor | Bombesin Receptor | inhibit

相关产品: TUG-499 | DJ-V-159 | BTB09089 | [Orn8]-Urotensin II acetate | GPCR agonist-2 | BMS-903452 | TUG-891 | 6-OAU | TC-O 9311 free base | LY2922470

相关库: Polyphenolic Natural Product Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Inhibitor Library | Human Endogenous Metabolite Compound Library Plus | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Natural Product Library

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