N-间氧基苄基-9顺-12顺-15顺-亚麻酸酰胺(玛卡酰胺 5) TN1964
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 383715-23-9 | ¥2,550.00 | 询底价 |
20 mg | 383715-23-9 | ¥3,850.00 | 询底价 |
Product Introduction
Bioactivity
英文名: N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide
描述: N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide is a natural product
体外活性: Herein, the isolation of seven NAAs and the assessment of their effects on major protein targets in the ECS network are reported. Four NAAs, octadeca-2E,4E,8E,10Z,14Z-pentaene-12-ynoic acid isobutylamide (1), octadeca-2E,4E,8E,10Z,14Z-pentaene-12-ynoic acid 2'-methylbutylamide (2), hexadeca-2E,4E,9Z-triene-12,14-diynoic acid isobutylamide (3), and hexadeca-2E,4E,9,12-tetraenoic acid 2'-methylbutylamide (4), were identified from Heliopsis helianthoides var. scabra. Compounds 2-4 are new natural products, while 1 was isolated for the first time from this species. The previously described macamides, N-(3-methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide, 5), N-benzyl-(9Z,12Z,15Z)-octadecatrienamide (6), and N-benzyl-(9Z,12Z)-octadecadienamide (7), were isolated from Lepidium meyenii (Maca). N-Methylbutylamide 4 and N-benzylamide 7 showed submicromolar and selective binding affinities for the cannabinoid CB1 receptor (Ki values of 0.31 and 0.48 μM, respectively). Notably, compound 7 also exhibited weak fatty acid amide hydrolase (FAAH) inhibition (IC50 = 4 μM) and a potent inhibition of anandamide cellular uptake (IC50 = 0.67 μM) that was stronger than the inhibition obtained with the controls OMDM-2 and UCM707. The pronounced ECS polypharmacology of compound 7 highlights the potential involvement of the arachidonoyl-mimicking 9Z,12Z double-bond system in the linoleoyl group for the overall cannabimimetic action of NAAs.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: N-(3-Methoxybenzyl)octadeca-9,12,15-trienamide | N(3Methoxybenzyl)(9Z,12Z,15Z)octadeca9,12,15trienamide | N (3 Methoxybenzyl)(9Z,12Z,15Z) octadeca 9,12,15 trienamide
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途