人参环氧炔醇 TN2039

Product Introduction
Bioactivity


英文名: Panaxydol

描述: Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria.

体外活性: Cell growth inhibition of panaxynol and Panaxydol were determined by trypan blue dye exclusion assays. Apoptosis of cells was revealed by morphological observation, analysis for nuclear DNA distribution and by annexin V-FITC/ PI staining using flow cytometry. It was found that panaxynol and Panaxydol markedly inhibited proliferation of HL60 cells in a time- and dose-dependent manner via an apoptotic pathway. In concern with these ndings, Western blot analysis showed proteolytic activation of PKCα′, caspase-3 activation and cleavage of poly (ADP [adenosine diphosphate]-ribose) polymerase in HL60 cells treated by panaxynol and Panaxydol[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Panaxydol

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