大豆皂苷AC TN2229

Product Introduction
Bioactivity


英文名: Soyasaponin Ac

描述: Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells.

体外活性: Cell viability assay was used to analyze the drug resistance of A2780/PTX cells treated with four different common soyasaponins respectively,in order to screen out the most effective soyasaponin. Then,the most effective soyasaponin was used to detect the expression of epithelial-mesenchymal transition (EMT)-related marker proteins, including N-cadherin and E-cadherin,with Western blot and confocal microscopy. Finally,transwell assay and wound healing assay were applied to observe effect of soyasaponin on regulating cancer cell migration. Compared with other soyasaponins,Soyasaponin Ac most effectively reversed the drug resistance of A2780/PTX cells. The expression of N-cadherin decreased while that of Ecadherin increased in A2780/PTX cells when treated with Soyasaponin Ac for 48 h. The results of transwell and wound healing assay suggested that Soyasaponin Ac also reduced the migration of A2780/PTX cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Soyasaponin Ac

大豆皂苷AC TN2229信息由TargetMol中国为您提供，如您想了解更多关于大豆皂苷AC TN2229报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途