化合物 TN6519 TN6519

Product Introduction
Bioactivity


英文名: Saucerneol

描述: Saucerneol has significant cardiovascular effects such as vasorelaxant and negative inotropic actions.

体外活性: Saururus chinensis has been widely used as a traditional medicine for the treatment of beriberi, hypertension, pneumonia, edema, jaundice and gonorrhea. However, there is only limited information on the cardiovascular effects of S. chinensis extract or its single compounds. METHODS AND RESULTS: The present study was performed to investigate the effects of active lignans isolated from the extract of S. chinensis on vascular responses and heart functions. The vasorelaxant activity-guided fractionation of roots extract of S. chinensis led to the isolation of eight lignans as active principles. These lignans produced concentration-dependent relaxations of the endothelium-intact aortic preparations of rat aorta. Particularly, Saucerneol (1), Saucerneol D (2) and machilin D (8) exhibited distinctive vasorelaxant activity (EC50 values: 2.2, 12.7 and 17.8 μM, respectively), which were significantly inhibited by removal of functional endothelium or pretreatment with N G-nitro-L-arginine methyl ester. Saucerneol (1) and Saucerneol D (2) caused a significant decrease in left ventricular pressure, +dP/dtmax and heart rate in isolated hearts. CONCLUSIONS: These results suggest that several lignans including Saucerneol (1), Saucerneol D (2) and machilin D (8), isolated from the ethanol extract of the roots of S. chinensis, have significant cardiovascular effects such as vasorelaxant and negative inotropic actions.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Saucerneol

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途