化合物 TP2245 TP2245
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | TP2245 | ¥753.00 | 询底价 |
10 mg | TP2245 | ¥3,633.00 | 询底价 |
5 mg | TP2245 | ¥2,193.00 | 询底价 |
25 mg | TP2245 | ¥5,073.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Endostatin (84-114)-NH2 (JKC367)
描述: Endostatin is a potent inhibitor of primary tumor growth and endothelial cell proliferation and migration. Recombinant endostatin potently inhibited angiogenesis, maintains metastases at a low level, and suppressed tumors, a reduction of over 150-fold. Endostatin showed no toxicity to mice, no evidence of drug resistance, and no regrowth of tumors.
体外活性: Endostatin and TNP-470 treatments inhibited atherosclerosis by 85% and 70%, respectively. Either treatment significantly inhibited plaque growth, but the degree of inhibition by endostatin was less than that by TNP-470. Significant inhibition of plaque growth by endostatin or TNP-470 was seen even when the treatment was delayed until 32 weeks, although the degree of inhibition was smaller. Both endostatin and TNP-470 are reversible inhibitors of endothelial cell proliferation and appear to exert few effects on quiescent nonproliferating endothelium. Endostatin administered continuously into the peritoneal cavity by a mini-osmotic pump is 50% more effective in tumor suppression than the same dose administered once a day i.p. [1].
体内活性: Furthermore, we show that a 10-fold lower dose, when given continuously, will accomplish the same tumor suppression as a single dose given i.p daily. Finally, we show that only continuous dosing can achieve tumor regression with human soluble endostatin. Endostatin retains biological activity in the osmotic pump for at least 7 days. Importantly, the endostatin does not undergo any obvious proteolytic degradation within an i.p. implanted pump. Soluble recombinant mouse endostatin has shown efficacy against a human renal carcinoma in mice when given i.p as a single bolus dose of 10 –20 mg/kg/day. However, only 30% of the animals in the treated group demonstrated tumor regression [3].
存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : ≥353.2mg/mL
关键字: Endostatin (84 114) NH2 (JKC367) | Endostatin (84114)NH2 (JKC367) | Endostatin (84-114)-NH-2 (JKC367) | JKC367 | Endostatin NH2 | JKC-367 | JKC 367
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途