化合物 TP2281 TP2281

Product Introduction
Bioactivity


英文名: p53 tumor suppressor fragment

描述: p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer.

体外活性: p53 has been described as 'the guardian of the genome' because of its role in conserving stability by preventing genome mutation. p53 has many mechanisms of anticancer function and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. In its anti-cancer role, p53 works through several mechanisms: It can activate DNA repair proteins when DNA has sustained damage. It can induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, the programmed cell death if DNA damage proves to be irreparable [1][2][3].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : ≥53.3mg/mL


关键字: p-53 tumor suppressor fragment | p53 tumor suppressor fragment

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途