化合物EIPA TQ0157

Product Introduction
Bioactivity


英文名: EIPA

描述: EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂，IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。

细胞实验: The effect of EIPA alone (without alanine or proline) is also examined in both control (DMEM cultured cells) and amino acid-starved cells. The cells are incubated for 6 h in DMEM containing 5% FBS and either 0 or 0.3 mM EIPA (labeled QNN and QNE, respectively), HBSS containing either 0 or 0.3 mM EIPA (labeled HNN and HNE, respectively), HBSS with 1.0 mM alanine (labeled HAN) or 0.5 mM proline (labeled HPN), HBSS with 1.0 mM alanine and 0.3 mM EIPA (labeled HAE), and HBSS with 0.5 mM proline and 0.3 mM EIPA (labeled HPE) [2].

体外活性: 研究发现，EIPA、benzamil和phenamil能快速且可逆地在-50 mV时阻断Ca2+-激活的TRPP3通道激活，其IC50分别为143、10.5、1.1及0.14 μM[1]。与HAN和HPN组相比，EIPA处理后HAE和HPE组中自噬空泡的数量显著增加。EIPA调控IEC-18细胞中与氨基酸相关的自噬启动及成熟过程[2]。此外，EIPA还能抑制cinnamoylphenazine (CA-PZ)和neutral red (NR)的摄取[3]。

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 135 mg/mL (450.36 mM)


关键字: colon carcinoma | IEC-18 | NHE3 | renal failure | IBDs | Cation channel | ddY strain mice | MKN28 | L-593754 | Autophagy | gastric cancer | Inhibitor | neuron | pancreatic carcinoma | EIPA | inhibit | IECs | TRP Channel | L 593754 | Sodium-hydrogen Exchanger | Prostaglandin Receptor | Cyclooxygenase | COX | Na+/H+ Exchanger (NHE) | zinc | Transient receptor potential channels | calcium | kainite | Sodium/hydrogen Exchanger

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相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Sodium Channel Blocker Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途