14-脱氧-11,12-二去氢穿心莲内酯 TQ0185
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 42895-58-9 | ¥15,600.00 | 询底价 |
1 mg | 42895-58-9 | ¥497.00 | 询底价 |
10 mg | 42895-58-9 | ¥2,280.00 | 询底价 |
100 mg | 42895-58-9 | ¥7,780.00 | 询底价 |
25 mg | 42895-58-9 | ¥3,880.00 | 询底价 |
5 mg | 42895-58-9 | ¥1,550.00 | 询底价 |
50 mg | 42895-58-9 | ¥5,580.00 | 询底价 |
1 mL | 42895-58-9 | ¥1,150.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 14-Deoxy-11,12-didehydroandrographolide
描述: 14-Deoxy-11,12-didehydroandrographolide (AP10) 是一种 Andrographolide 的类似物,能够抑制 NF-κB 活性。
细胞实验: A549 cells (3×10^3/well), BEAS-2B cells (5×10^3/well), and RBL-2H3 cells (3×10^3/well) are seeded in flat-bottomed 96-well plates overnight and then incubated with increasing concentrations (3-120 μM) of 14-deoxy-11,12-didehydroandrographolide for 24 and 48 h at 37°C. Cell viability is analyzed using the CellTiter 96 AQueous cell proliferation assay. Absorbance is recorded at 490 nm.
动物实验: Female BALB/c mice, 6 to 8 weeks old, are sensitized and challenged with OVA. Briefly, mice are sensitized by ip injections of 20 μg of OVA and 4 mg of Al(OH)3 suspended in 0.1 mL of saline on days 0 and 14. On days 22, 23, and 24, mice are challenged with 1% OVA aerosol for 30 min. 14-deoxy-11,12-didehydroandrographolide (0.1, 0.5, and 1 mg/kg) or vehicle (1% DMSO) in 0.1 mL of saline is given by i.p injections 2 h before and 10 h after each OVA aerosol challenge.
体内活性: 14-Deoxy-11,12-didehydroandrographolide(1 mg/kg)在对甲基胆碱的反应中,显著降低了卵清蛋白挑战的小鼠的阻力,并恢复了Cdyn。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 100 mg/mL (300.82 mM)
关键字: AP-10 | inhibit | Nuclear factor-κB | Inhibitor | 14 Deoxy 11,12 didehydroandrographolide | NF-κB | Nuclear factor-kappaB | 14Deoxy11,12didehydroandrographolide | AP 10 | 14-Deoxy-11,12-didehydroandrographolide
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途