千里光宁 TQ0192

Product Introduction
Bioactivity


英文名: Senecionine

描述: Senecionine (Senecionin) 是一种吡咯里西啶生物碱，从Senecio vulgaris 中分离得到，它对动物和人类有毒性。

动物实验: Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4) [4].

体外活性: 细胞毒性在无外源性Ca2+环境下比存在外源性Ca2+时更高，表明Senecionine引起的肝脏毒性是由于细胞内Ca2+分布的改变，而非外源性Ca2+的流入所致[1]。

体内活性: Senecionine未能激活环氧化酶，它降低了谷胱甘肽-S-转移酶、氨基吡啶去甲基酶以及AHH的活性[2]。每周两次注射Senecionine，从第12天或之后开始，在七只大鼠中有三只发生早产，所有窝的幼仔均为死胎或出生后不久即死亡[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 1 mg/mL (2.98 mM)
DMSO : 5 mg/mL (14.91 mM)


关键字: Senecionine | Inhibitor | inhibit

相关库: PBCRBS Traditional Chinese Medicine Compound Library | Anti-Tumor Natural Product Library | Selected Plant-Sourced Compound Library | Chinese Pharmacopoeia Natural Product Library | Covalent Natural Product Library | Alkaloid Natural Product Library | Natural Product Library for HTS | Traditional Chinese Medicine Monomer Library | Tibetan medicine Compound Library | Covalent Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途