原花青素 B1 TQ0205

Product Introduction
Bioactivity


英文名: Procyanidin B1

描述: Procyanidin B1 是水果中常见的多酚类黄酮，能够与TLR4/MD-2复合体结合，具有抗炎活性。

细胞实验: To investigate the cytotoxic effect of Procyanidin B1, the viability of THP1 cells is assessed using the CCK8 assay. THP1 cells are treated with Procyanidin B1 for 18 h, and 10 μL of CCK8 solution is then added to each well and the cultures are incubated for 4 h at 37°C. The optical density (OD) at 450 nm is measured using an ELx808 Absorbance Microplate Reader. The Procyanidin B1 concentration tested ranges from 50 to 200 μg/mL. Each sample is tested in triplicate [1].

体外活性: Procyanidin B1 (100 μg/mL) 抑制LPS诱导的TNF-α产生、MD-2、TRAF6、NF-κB mRNA的表达以及THP1细胞中磷酸化的p38 MAPK和NF-κB蛋白[1]。Procyanidin B1 (50-100 μM) 能够保护神经元免受Aβ寡聚体诱导的死亡。Procyanidin B1 在100 μM时强效抑制caspase-3的激活，在30、50、和100 μM时抑制caspase-8，在10、30、50、和100 μM时抑制caspase-9[2]。Procyanidin B1 (10、20、30 μM) 显著且剂量依赖性地诱导ACO和CPT1的表达，对PPARα mRNA的表达无明显影响[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 23 mg/mL (39.76 mM)


关键字: Toll-like Receptor (TLR) | Inhibitor | Procyanidin B-1 | inhibit | Procyanidin B1 | Procyanidin B 1

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相关库: Anti-Aging Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Immuno-Oncology Compound Library | Membrane Protein-targeted Compound Library | Chinese Pharmacopoeia Natural Product Library | Human Endogenous Metabolite Compound Library Plus | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | Food as Medicine Compound Library | Flavonoid Natural Product Library

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